The Association of Imaging Producers & Equipment Suppliers (AIPES) held a meeting in Brussels, Belgium, on September 3 to discuss the shortage of molybdenum-99 in Europe.
European nuclear medicine facilities have been hit by the unplanned shutdowns in recent weeks of two reactors that supply molybdenum-99, the precursor to technetium-99m, one of the most widely used radiopharmaceuticals. The High Flux Reactor (HFR) in the Netherlands shut down on August 22, while the BR2 reactor at the Institut National des Radioéléments (IRE) in Belgium shut down just a few days later following a leak of radioactive iodine. Both reactors were built in 1961.
At the AIPES meeting, attendees discussed ways to cope with the shortage, which the association estimated would result in a 30% reduction in technetium-99m deliveries. The shortage is expected to last four to six weeks.
AIPES and the European Association of Nuclear Medicine (EANM) are working on recommendations for nuclear medicine physicians on replacement isotopes for technetium-99m. There may still be delays or cancellations of diagnostic exams, however, according to AIPES president Marc Gheeraert.
"Despite the efforts made to overcome this temporary shortage, a long-term strategy to replace the very old isotope reactors needs to be implemented at [the European Union] level," Gheeraert said. "AIPES had already started an independent assessment of future isotope needs and required production capacity which will be presented to all stakeholders upon its completion in the coming months."
Related Reading
AECL: Increased production won't cover demand, August 29, 2008
Belgium restricts local food after radioactive leak, August 29, 2008
SNM has 'serious concerns' over isotope situation, August 28, 2008
AECL monitors isotope supply after Dutch shutdown, August 26, 2008
SNM draft report shows U.S. Mo-99 production years away, July 22, 2008
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![Overview of the study design. (A) The fully automated deep learning framework was developed to estimate body composition (BC) (defined as subcutaneous adipose tissue [SAT] in liters; visceral adipose tissue [VAT] in liters; skeletal muscle [SM] in liters; SM fat fraction [SMFF] as a percentage; and intramuscular adipose tissue [IMAT] in deciliters) from MRI. The fully automated framework comprised one model (model 1) to quantify different BC measures (SAT, VAT, SM, SMFF, and IMAT) as three-dimensional (3D) measures from whole-body MRI scans. The second model (model 2) was trained to identify standardized anatomic landmarks along the craniocaudal body axis (z coordinate field), which allowed for subdividing the whole-body measures into different subregions typically examined on clinical routine MRI scans (chest, abdomen, and pelvis). (B) BC was quantified from whole-body MRI in over 66,000 individuals from two large population-based cohort studies, the UK Biobank (UKB) (36,317 individuals) and the German National Cohort (NAKO) (30,291 individuals). Bar graphs show age distribution by sex and cohort. BMI = body mass index. (C) After the performance assessment of the fully automated framework, the change in BC measures, distributions, and profiles across age decades were investigated. Age-, sex-, and height-adjusted body composition reference curves were calculated and made publicly available in a web-based z-score calculator (https://circ-ml.github.io).](https://img.auntminnieeurope.com/mindful/smg/workspaces/default/uploads/2026/05/body-comp.XgAjTfPj1W.jpg?auto=format%2Ccompress&fit=crop&h=112&q=70&w=112)




