MRI in the Diagnosis and Monitoring of Multiple Sclerosis IIOct 6th, 2019Nov 3rd, 2019Onlinehttps://academy.telemedicineclinic.com/online-mini-fellowships/2890/mri-in-the-diagnosis-and-monitoring-of-multiple-sclerosis-ii-oct-2019/This is part 2 of the online minifellowship on MRI in the diagnosis and monitoring of multiple sclerosis.Latest in HomeWelding fumes linked to distinct lung CT changes, functionMay 7, 2026SponsoredTurning Innovation into Everyday EfficiencyMay 2, 2026MRI reveals how hidden muscle fat increases risk to heart, metabolismMay 5, 2026The EANM joins EMUC26 and pushes its policy agenda in BrusselsMay 5, 2026
![Overview of the study design. (A) The fully automated deep learning framework was developed to estimate body composition (BC) (defined as subcutaneous adipose tissue [SAT] in liters; visceral adipose tissue [VAT] in liters; skeletal muscle [SM] in liters; SM fat fraction [SMFF] as a percentage; and intramuscular adipose tissue [IMAT] in deciliters) from MRI. The fully automated framework comprised one model (model 1) to quantify different BC measures (SAT, VAT, SM, SMFF, and IMAT) as three-dimensional (3D) measures from whole-body MRI scans. The second model (model 2) was trained to identify standardized anatomic landmarks along the craniocaudal body axis (z coordinate field), which allowed for subdividing the whole-body measures into different subregions typically examined on clinical routine MRI scans (chest, abdomen, and pelvis). (B) BC was quantified from whole-body MRI in over 66,000 individuals from two large population-based cohort studies, the UK Biobank (UKB) (36,317 individuals) and the German National Cohort (NAKO) (30,291 individuals). Bar graphs show age distribution by sex and cohort. BMI = body mass index. (C) After the performance assessment of the fully automated framework, the change in BC measures, distributions, and profiles across age decades were investigated. Age-, sex-, and height-adjusted body composition reference curves were calculated and made publicly available in a web-based z-score calculator (https://circ-ml.github.io).](https://img.auntminnieeurope.com/mindful/smg/workspaces/default/uploads/2026/05/body-comp.XgAjTfPj1W.jpg?auto=format%2Ccompress&dpr=2&fit=crop&h=167&q=70&w=250)
