Clinical Laserthermia Systems (CLS) said it's conducting new in vivo precision laser ablation treatment studies using its Tranberg thermal therapy system with MRI-guided Thermoguide thermometry software in neurological and prostate applications.
The Tranberg thermal therapy system is a small, mobile laser unit with monitoring capabilities and single-use products developed to enable precision laser ablation procedures using all types of image guidance, according to the vendor. It can control and monitor tissue temperatures within the ablation volume and the surrounding tissue.
The company said it currently expects to submit a 510(k) application for its technology to the U.S. Food and Drug Administration (FDA) during the first half of 2021. This timeline could be affected by the COVID-19 pandemic, however, CLS said.
In April, CLS obtained European Union approval and a European Commission certificate for its Tranberg system, Thermoguide software, and related products to be marketed and sold in Europe for indications such as prostate cancer, brain tumors, and epilepsy.
![Overview of the study design. (A) The fully automated deep learning framework was developed to estimate body composition (BC) (defined as subcutaneous adipose tissue [SAT] in liters; visceral adipose tissue [VAT] in liters; skeletal muscle [SM] in liters; SM fat fraction [SMFF] as a percentage; and intramuscular adipose tissue [IMAT] in deciliters) from MRI. The fully automated framework comprised one model (model 1) to quantify different BC measures (SAT, VAT, SM, SMFF, and IMAT) as three-dimensional (3D) measures from whole-body MRI scans. The second model (model 2) was trained to identify standardized anatomic landmarks along the craniocaudal body axis (z coordinate field), which allowed for subdividing the whole-body measures into different subregions typically examined on clinical routine MRI scans (chest, abdomen, and pelvis). (B) BC was quantified from whole-body MRI in over 66,000 individuals from two large population-based cohort studies, the UK Biobank (UKB) (36,317 individuals) and the German National Cohort (NAKO) (30,291 individuals). Bar graphs show age distribution by sex and cohort. BMI = body mass index. (C) After the performance assessment of the fully automated framework, the change in BC measures, distributions, and profiles across age decades were investigated. Age-, sex-, and height-adjusted body composition reference curves were calculated and made publicly available in a web-based z-score calculator (https://circ-ml.github.io).](https://img.auntminnieeurope.com/mindful/smg/workspaces/default/uploads/2026/05/body-comp.XgAjTfPj1W.jpg?auto=format%2Ccompress&dpr=2&fit=crop&h=167&q=70&w=250)
