The clinical trial so far has used lutetium-177 (Lu-177) prostate-specific membrane antigen 617 (PSMA-617) on 145 patients at 12 therapy centers across Germany. Some side effects have been reported, but the researchers have deemed them manageable (JNM, Vol. 58:1, pp. 85-90).
PSMA is abundant in prostate cancer and even more prevalent in the castration-resistant form of the disease, which has a median survival rate of less than two years.
Lutetium-177 PSMA-617 radionuclide therapy has been shown to reduce tumor burden and induce prostate-specific antigen remission in patients with metastatic advanced prostate cancer. Image courtesy of JNM.
The 145 subjects (median age, 73 years; range, 43-88 years) were treated with Lu-177 PSMA-617 between February 2014 and July 2015 with one to four therapy cycles. A total of 248 therapy cycles were performed on the patients.
Overall, 45% of the patients had a positive response after all therapy cycles, while 40% responded positively after a single cycle. In terms of side effects, 18 patients had hematotoxicity; 10% had anemia, 4% experienced thrombocytopenia, and 3% had leukopenia. In addition 8% of patients experienced dry mouth.
Future phase II/III studies are needed to clarify the survival benefit of the new therapy for this type of patient, concluded lead author Dr. Kambiz Rahbar and colleagues.If you like this content, please share it with a colleague!
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