The study, published in Cancer Epidemiology, Biomarkers and Prevention, has associated volumetrically assessed breast density measurements made by VolparaDensity with breast cancer risk (10 July 2014).
The prospective cohort Karolinska Mammography Project for Risk Prediction of Breast Cancer (KARMA) study was initiated in January 2011 and included 70,876 women attending mammography screening or clinical mammography at four hospitals in Sweden. Digital mammography was performed using five different models from three vendors (GE Healthcare, Philips Healthcare, and Sectra). Volumetric breast density was measured using VolparaDensity. Study participants also donated blood for genotyping and filled out a detailed questionnaire.
Volumetric density was positively associated with never having given birth, age at first birth, hormone use, benign breast disease, and family history of breast cancer. Volumetric density was negatively associated with age and postmenopausal status.
The researchers found good agreement by side and by view, and distributions of volume density were similar across the different mammography systems, Volpara said. Based on the results, automated measurement of volumetric mammographic density using VolparaDensity is a promising tool for widespread breast cancer risk assessment, the researchers concluded.
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